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Istradefylline forty mg/day elevated peak amounts and AUC of CYP3A4 substrates in medical trials. This result was not noticed with istradefylline twenty mg/working day. Think about dose reduction of sensitive CYP3A4 substrates.modafinil will lower the level or influence of mavacamten by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contr
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